Mechanochemical Grinding Diels–Alder Reaction: Highly Efficient and Rapid Access to Bi-, Tri-, and Tetracyclic Systems

Jyoti Agarwal; Rashmi Rani; Rama Krishna Peddinti

doi:10.1055/s-0036-1558970

Synlett, Table of Contents

Synlett 2017; 28(11): 1336-1340
DOI: 10.1055/s-0036-1558970

letter

Mechanochemical Grinding Diels–Alder Reaction: Highly Efficient and Rapid Access to Bi-, Tri-, and Tetracyclic Systems

Jyoti Agarwal

Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee-247667, Uttarakhand, India Email: rkpedfcy@iitr.ac.in Email: ramakpeddinti@gmail.com

,

Rashmi Rani

Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee-247667, Uttarakhand, India Email: rkpedfcy@iitr.ac.in Email: ramakpeddinti@gmail.com

,

Rama Krishna Peddinti*

Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee-247667, Uttarakhand, India Email: rkpedfcy@iitr.ac.in Email: ramakpeddinti@gmail.com

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Abstract

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Abstract

Grinding of various electron-deficient dienophiles with diverse dienes in a pestle and mortar for 1–15 minutes afforded the corresponding Diels–Alder adducts in quantitative yields under catalyst-free and solvent-free conditions, without the necessity for any purification steps.

Key words

solvent-free reaction - Diels–Alder reaction - cycloaddition - polycyclic compounds - green chemistry

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References

References and notes

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27 Method A: Solid–Liquid or Solid–Solid Reactant Combinations; General Procedure A mixture of the diene (1 mmol) and the dienophile (1 mmol) was subjected to hand grinding with a pestle and mortar for the time shown in Tables 1 and 2 to afford the corresponding products in quantitative yield. In the reactions of cyclopentadiene, 1.2 equiv of the diene was used. In most cases, product formation was observed by the change in color; with aryl maleimides, the yellow color of the initial reaction mixture changed to white, whereas with 1,3-diphenyl-2-benzofuran, the color of the mixture changed almost immediately from fluorescent green to white. 2-(4-Bromophenyl)-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3-dione (7b) White solid; yield: 317 mg (quant); mp 156 °C. ¹H NMR (500 MHz, CDCl₃): δ = 7.55 (dt, J = 2.5, 9.0 Hz, 2 H), 7.04 (dt, J = 2.5, 9.5 Hz, 2 H), 6.25 (t, J = 1.5 Hz, 2 H), 3.53–3.47 (m, 2 H), 3.43 (q, J = 1.5 Hz, 2 H), 1.79 (d, J = 9.0 Hz, 1 H), 1.61 (d, J = 9.0 Hz, 1 H). ¹³C NMR (125 MHz, CDCl₃): δ = 176.3, 134.5, 132.1, 130.7, 128.1, 122.2, 52.1, 45.7, 45.4. 2-(4-Methoxyphenyl)-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3-dione (7d) White solid; yield: 170 mg (quant); mp 269 °C. ¹H NMR (500 MHz, CDCl₃): δ = 7.04 (d, J = 8.0 Hz, 2 H), 6.93 (d, J = 8.0 Hz, 2 H), 6.25 (s, 2 H), 3.80 (s, 3 H), 3.50 (s, 2 H), 3.41 (s, 2 H), 1.78 (d, J = 8.5 Hz, 1 H), 1.60 (d, J = 8.0 Hz, 1 H). ¹³C NMR (125 MHz, CDCl₃): δ = 177.1, 159.4, 134.5, 127.8, 124.4, 114.4, 55.4, 52.2, 45.6, 45.4. Diethyl 1,4-Diphenyl-1,4-dihydro-1,4-epoxynaphthalene-2,3-dicarboxylate (18) White solid; yield: 440 mg (quant); mp 115 °C. ¹H NMR (500 MHz, CDCl₃): δ = 7.79 (d, J = 7.0 Hz, 4 H), 7.56 (dd, J = 3.0, 5.0 Hz, 2 H), 7.52–7.43 (m, 6 H), 7.18 (dd, J = 3.0, 5.0 Hz, 2 H), 4.23–4.12 (m, 4 H), 1.17 (t, J = 7.0 Hz, 6 H). ¹³C NMR (125 MHz, CDCl₃): δ = 163.6, 153.7, 149.2, 133.2, 129.0, 128.4, 128.1, 125.9, 122.1, 94.0, 61.3, 13.8. Bicyclo[2.2.1]hept-5-ene-2,2,3,3-tetracarbonitrile (19) White solid; yield: 194 mg (quant); mp 217 °C. ¹H NMR (500 MHz, CDCl₃): δ = 6.52 (s, 2 H), 4.06 (s, 2 H), 2.25 (s, 2 H). ¹³C NMR (125 MHz, CDCl₃): δ = 133.6, 111.9, 111.7, 110.9, 110.4, 107.9, 55.9, 46.7, 46.4. Bicyclo[2.2.2]oct-5-ene-2,2,3,3-tetracarbonitrile (21) White solid; yield: 208 mg (quant). ¹H NMR (500 MHz, CDCl₃): δ = 6.69 (s, 2 H), 3.55 (s, 2 H), 2.24 (d, J = 9.5 Hz, 2 H), 1.62 (d, J = 9.5 Hz, 2 H). ¹³C NMR (125 MHz, CDCl₃): δ = 133.1, 111.7, 111.3, 107.9, 42.8, 39.1, 18.8.
28 Method B: Liquid-Assisted Grinding; General Procedure A mixture of the appropriate diene (1 mmol), dienophile (1 mmol), and EtOAc (2–3 drops) was subjected to hand grinding with a pestle in a mortar for the time shown in Tables 1 and 2. Almost immediately, the color of the mixture changed from fluorescent-green or yellow to white. The EtOAc was removed under vacuum to afford the pure solid product in quantitative yield. 2-(4-Bromophenyl)-4,9-diphenyl-3a,4,9,9a-tetrahydro-1H-4,9-epoxybenzo[f]isoindole-1,3-dione (5b) White solid; yield: 521 mg (quant); mp 242 °C. ¹H NMR (500 MHz, CDCl₃): δ = 8.05 (d, J = 7.5 Hz, 4 H), 7.54 (t, J = 7.5 Hz, 4 H), 7.47 (d, J = 7.0 Hz, 2 H), 7.28–7.22 (m, 4 H), 7.05 (dd, J = 3.0, 5.0 Hz, 2 H), 6.43 (d, J = 8.5 Hz, 2 H), 4.26 (s, 2 H). ¹³C NMR (125 MHz, CDCl₃): δ = 173.0, 144.0, 136.2, 132.1, 130.1, 128.8, 128.7, 128.3, 127.9, 127.1, 122.7, 120.8, 90.6, 54.3. 2-(4-Methoxyphenyl)-4,9-diphenyl-3a,4,9,9a-tetrahydro-1H-4,9-epoxybenzo[f]isoindole-1,3-dione (5d) White solid; yield: 473 mg (quant); mp 209 °C. ¹H NMR (500 MHz, CDCl₃): δ = 8.07 (d, J = 8.0 Hz, 4 H), 7.53 (t, J = 7.5 Hz, 4 H), 7.46 (t, J = 7.0 Hz, 2 H), 7.29–7.22 (m, 2 H), 7.06 (dd, J = 3.0, 5.0 Hz, 2 H), 6.79 (d, J = 8.5 Hz, 2 H), 6.42 (d, J = 9.0 Hz, 2 H), 4.24 (s, 2 H), 3.75 (s, 3 H). ¹³C NMR (125 MHz, CDCl₃): δ = 173.5, 159.5, 144.1, 136.3, 128.6, 128.5, 128.1, 127.5, 127.1, 123.7, 120.8, 114.2, 90.5, 55.3, 54.2. 1,4-Diphenyl-1,2,3,4-tetrahydro-1,4-epoxynaphthalene-2,3-dicarbonitrile (16) White solid; yield: 378 mg (quant). ¹H NMR (500 MHz, CDCl₃): δ = 7.84–7.79 (m, 2 H), 7.69–7.62 (m, 2 H), 7.60–7.59 (m, 6 H), 7.32–7.29 (m, 3 H), 7.15 (d, J = 7.0 Hz, 1 H), 3.87 (d, J = 4.5 Hz, 1 H), 3.54 (d, J = 4.0 Hz, 1 H). ¹³C NMR (125 MHz, CDCl₃): δ = 144.1, 142.8, 134.1, 133.3, 129.6, 129.2, 129.1, 129.0, 125.8, 125.5, 121.8, 119.7, 117.1, 117.0, 90.7, 44.4, 43.0.

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